The Philadelphia Chromosome

The Philadelphia Chromosome

A Mutant Gene and the Quest to Cure Cancer at the Genetic Level

Book - 2013
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This work focuses on what is widely viewed as the poster child of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of chronic myeloid leukemia disease, and the subsequent development of Gleevec, is the keynote of this astounding publication.
Contents: Down to the bone : February 2012
The chromosome and the disease : 1959-1990. The first clue ; Three hundred words ; Investigating a chicken virus ; Right number, wrong place ; The surprising source of the chicken cancer gene ; Consummate instigators ; Where the kinase hangs the keys ; A chemical amputation ; Stripping away the fur and the fat ; A funny new protein ; The first sign of a human cancer gene ; Spelling out the translocation ; "That word is oncogenes"
Rational design : 1983-1998. Becoming a doctor, and then a scientist ; Turning a protein into a drug target ; A machine with a virus for a motor ; Plucking the low-hanging fruit ; A drug in search of a disease; Two endings ; Getting out of Boston ; Killing cells ; Gain and loss ; "Not over my dead body will this compound go into man"
Human trials : 1998-2001. The quickest answer ; Getting to 200 milligrams ; The one thing they didn't have ; Buzz in the chat rooms ; Saving their own lives ; A response rate of one hundred percent ; Good stressful ; Putting it in writing ; A truckload of data ; The fathers of victory
Aftermath. A price to pay ; Showing a weakness ; The first five years ; The second generation ; A Gleevec for every cancer
Survival time
Publisher: New York : The Experiment : Distributed by Workman Pub., 2013
Branch Call Number: 616.99419 W
Characteristics: xiii, 303 p., [8] p. of plates : ill. (some col.) ; 24 cm
ISBN: 9781615190676


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Donald W Mayfield
Aug 17, 2014

I highly recommend this book. It describe that current state of cancer research and the history behind the targeted drugs of today.

It is well written.


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